Published in Frontiers in Cell and Developmental Biology, this paper demonstrates a new approach to developing scalable manufacturing processes for induced pluripotent stem cell-derived natural killer (iNK) cells.
Researchers from the Cell and Gene Therapy Catapult and Plasticell identified feeder-free protocols capable of producing mature, functional iNK cells, before successfully translating the process to stirred-tank bioreactors and achieving a 10-fold increase in productivity.
The work highlights a potential route towards more scalable and reproducible manufacture of iNK cell therapies.
