An Introduction to Upstream Processing for Viral Vector Manufacturing
This two-day, course will cover the essential biology of viral vectors and an overview of the key steps in the upstream manufacturing of viral vectors, focusing primarily on AAV and Lentivirus. It will also offer an insight into the regulatory expectations of viral vector manufacturing plus current manufacturing trends and challenges.
Learning objectives:
- Be able to describe the development of viral vectors and their use for research and therapeutic applications.
- Appreciate the importance of viral vector critical quality attributes and their relationship with critical material attributes and critical process parameters.
- Explore the range of manufacturing procedures employed during the upstream manufacture of viral vector products including cell counting and assessment of cell viability, passaging, transfection and considerations for bioreactor readiness, set-up and operation.
- Recognise and utilise appropriate strategies to address the challenges of manufacturing viral vectors within a GMP environment.
- Be aware of developments in upstream manufacturing operations to enhance process efficiency and product quality.
Who should attend:
This course is suitable for advanced therapy scientists working in manufacturing operations and process development, in addition to technology suppliers and anyone else who wishes to learn about the principles of viral vector manufacture and the techniques employed throughout the upstream workflow.