An Introduction to Downstream Processing for Viral Vector Manufacturing

This two-day course introduces the essential biology of viral vectors and the key steps in downstream manufacturing, with a focus on AAV and Lentivirus. It will also provide an insight into regulatory expectations, current manufacturing practices, and emerging challenges in the field.

Learning objectives:

• Describe the development of viral vectors and their applications in research and therapies.
• Understand the importance of viral vector critical quality attributes and their links to materials attributes and process parameters.
• Explore downstream manufacturing procedures, including clarification, tangential flow filtration, chromatography, sterile filter integrity testing, and aseptic-manifold design and operation.
• Identify and apply strategies to address GMP challenges in viral vector manufacturing.
• Recognize developments in downstream operations that improve efficiency and product quality.

Who should attend:

This course is suitable for advanced therapy scientists in manufacturing and process development, technology suppliers, and anyone seeking to understand viral vector principles and downstream manufacturing techniques.

Course contributors:

With thanks to Cytiva, the National Horizons Centre and BPES for their support in developing and delivering this course.