An Introduction to Upstream Processing for Viral Vector Manufacturing

This two-day course will introduce the essential biology of viral vectors and explore the key steps in upstream manufacturing, with a focus on AAV and Lentivirus. You will also gain insight into regulatory expectations, examine current manufacturing trends, and discuss the challenges shaping viral vector production.

Learning objectives:

• Describe the development of viral vectors and their applications in research and therapy
• Explain viral vector critical quality attributes and their link to material attributes and process parameters
• Explore upstream manufacturing procedures, including cell counting, viability assessment, passaging, transfection, and bioreactor readiness, set-up and operation.
• Recognise and apply strategies to address GMP challenges in viral vector manufacturing
• Recognize developments in upstream operations that improve efficiency and product quality

Who should attend:

This course is suitable for advanced therapy scientists in manufacturing and process development, technology suppliers, and anyone seeking to understand viral vector principles and upstream manufacturing techniques.